Immolative cell-penetrating complexes for nucleic acid delivery to the lung

US11931416B2 · kind B2 · utility

Assignee

• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Tim R. Blake · Palo Alto, US
• Paul A. Wender · Menlo Park, US
• Robert M. Waymouth · Palo Alto, US
• Ronald Levy · Palo Alto, US
• Ole Haabeth · Emeryville, US
• Rebecca L. McClellan · Westwood, US
• Adrienne Sallets · Palo Alto, US

Key dates

• Filing date: Jan 31, 2020
• Grant date: Mar 19, 2024
• Expiry date: Jun 7, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08G73/0293
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There are provided herein, inter alia, cationic amphipathic polymers, complexes, and compositions comprising same, and methods for their use including for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acids, into a cell. The complexes, compositions and methods may facilitate delivery and targeted release of the therapeutic, diagnostic and imaging agents to particular cell types and tissues.