Patent · US Active

Biosynthesis of curcuminoids in mammalian cells

US11932897B2 · kind B2 · utility

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19Claims

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Assignee

University of Kentucky Research Foundation · US

Inventors

Logan W. Warriner · Lexington, US
Daniel W. Pack · Lexington, US

Key dates

Filing date	Dec 18, 2019
Grant date	Mar 19, 2024
Priority date	—
Expiry date	Jan 3, 2042

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y604/01002
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A method of making curcuminoids in a mammalian cell. The method of making a curcuminoid in a mammalian cell includes expressing one or more enzymes in the mammalian cell, the enzymes being selected from the group consisting of tyrosine ammonia lyase (TAL), 4-coumaroyl-CoA ligase (4CL1), curcuminoid synthase (CUS), diketide-CoA synthase (DCS), curcumin synthase (CURS1), 4-coumarate 3-hydroxylase (C3H), caffeoyl-CoA 3-O-methyltransferase (CCoAMT), and acetyl-CoA carboxylase (ACC). The expressing of the one or more enzymes converts a starting material, such as tyrosine or ferulic acid, to the curcuminoid. Also provided herein are therapeutic uses for the curcuminoid made in a mammalian cell.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.