Non-nutritive sweeteners and polyols as imaging agents

US11938200B2 · kind B2 · utility

Assignees

• The Trustees of the University of Pennsylvania · US
• Sidra Medicine · QA

Inventors

• Ravinder Reddy · Conshohocken, US
• Mohammad Haris · Philadelphia, US
• Hari Hariharan · Irvine, US
• Puneet Bagga · Philadelphia, US
• Francesco M. MARINCOLA · Palo Alto, US
• Mitchell Schnall · Broomall, US

Key dates

• Filing date: Feb 3, 2017
• Grant date: Mar 26, 2024
• Expiry date: Feb 5, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61B6/037
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to magnetic resonance imaging (MRI) methods comprising (i) obtaining a baseline chemical exchange saturation transfer (CEST) MRI image of a patient, (ii) administering an effective amount of a non-nutritive sweetener to the patient, and (iii) obtaining one or more test CEST MRI image of the patient subsequent to the administering step (ii); wherein the step (i) and (iii) acquisition parameters are substantially the same. The non-nutritive sweetener may include a natural or artificial sugar alcohol, polyol, or combinations or derivatives thereof.