Sustained-release anesthetic compositions and methods of preparation thereof
US11938220B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 30, 2019 |
| Grant date | Mar 26, 2024 |
| Priority date | — |
| Expiry date | Mar 30, 2039 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P23/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided is an anesthetic composition for locally administering a local anesthetic agent to a subject in need thereof. The anesthetic composition has a lipid based complex prepared by hydrating a lipid cake containing a local anesthetic agent and a lipid mixture with an aqueous buffer solution at a pH higher than 5.5. Also provided is a method to prepare an anesthetic composition using a simpler and more robust for large-scale manufacture and for providing a high molar ratio of local anesthetic agent to phospholipid content as compared to the prior art. This anesthetic composition has a prolonged duration of efficacy adapted to drug delivery.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.