AXL-targeting antibody, antibody-drug conjugate, preparation method therefor, and use thereof

US11939386B2 · kind B2 · utility

Assignee

• SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN

Inventors

• Ke Yu · Alpharetta, US
• Jingkang Shen · Shanghai, CN
• Tao Meng · North Plainfield, US
• Jinpeng Pei · Shanghai, CN
• Lanping Ma · Shanghai, CN
• Xin Wang · Shanghai, CN
• Rui Jin · Newark, US
• Zhiyan Du · Shanghai, CN
• Lin CHEN · Chengdu, CN
• Ting YU · Shanghai, CN
• Yongliang Zhang · Beijing, CN

Key dates

• Filing date: May 10, 2019
• Grant date: Mar 26, 2024
• Expiry date: Apr 9, 2041

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/91205
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are a new AXL-targeting monoclonal antibody and antibody-drug conjugate. Also disclosed is a method for preparing said antibody and antibody-drug conjugate. The AXL antibody of the present invention can bind with purified human AXL protein and multiple AXL on tumor cell surface with high effectiveness and high specificity. Said humanized antibody also has high affinity and low immunogenicity. Said AXL antibody-drug conjugate has markable performance against tumors having high AXL expression.