COTL1 protein involved in maintaining homeostasis of hematopoietic stem cell, and use thereof
US11939633B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 10, 2018 |
| Grant date | Mar 26, 2024 |
| Priority date | — |
| Expiry date | Jul 21, 2040 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/22
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A COTL1 gene or protein maintains and regulates the homeostasis of hematopoietic stem cells. A method of diagnosis and treatment of blood-related disease caused either by abnormalities in the homeostasis of hematopoietic stem cells, which result from a mutation in the COTL1 gene or a decrease in the expression of the COTL1 protein, or by an imbalance between the differentiation or proliferation and damage or death of hematopoietic stem cells, or by abnormalities in mitochondrial homeostasis are disclosed. The COTL1 gene or protein plays an important role in regulating mitochondrial morphology, and when it is knocked down, the number of hematopoietic stem cells decreases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.