Systems and method for generation of hyperpolarized materials

US11940510B2 · kind B2 · utility

Assignees

• NVision Imaging Technologies GmbH · DE
• Universität Ulm · DE

Inventors

• Ilai SCHWARTZ · Neu-Ulm, DE
• Michael KEIM · Geroldshausen, DE
• Martin Plenio · Ulm, DE
• Benedikt TRATZMILLER · Ulm, DE

Key dates

• Filing date: Mar 31, 2021
• Grant date: Mar 26, 2024
• Expiry date: Mar 31, 2041

Classification

• Technology area (CPC G): Physics
• CPC primary: G01R33/445
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method for preparing an NMR material, comprising generating parahydrogen in gas or liquid form at a first location; transporting the parahydrogen away from the first location; mixing a precursor compound including a metabolite component with a catalyst for hydrogenation; hydrogenating the precursor compound using the parahydrogen; transferring polarization in the precursor compound to a nuclear spin of the metabolite component; cleaving a side arm of the precursor compound in a chemical reaction, with the metabolite molecule being one of the products of the reaction; separating the metabolite molecule from the catalyst for hydrogenation and other products of the reaction; and generating metabolite molecules for use in an MRI scanner by extracting a sample of the metabolite molecule having at least 5% polarization.