Articles of manufacture and methods for treatment using adoptive cell therapy

US11944647B2 · kind B2 · utility

Assignee

• Juno Therapeutics, Inc. · US

Inventors

• Tina Albertson · Bothell, US
• Brian CHRISTIN · Seattle, US
• Jacob Garcia · Dracut, US
• Christopher Glen RAMSBORG · Seattle, US
• Claire L. SUTHERLAND · Seattle, US
• Clinton WEBER · Seattle, US
• Rachel K. YOST · Seattle, US
• Mark J. GILBERT · Seattle, US
• He Li · Shanghai, CN

Key dates

• Filing date: Jun 22, 2022
• Grant date: Apr 2, 2024
• Expiry date: Jun 22, 2042

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2239/38
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are adoptive cell therapy methods involving the administration of doses of cells for treating disease and conditions, including certain B cell malignancies. The cells generally express recombinant receptors such as chimeric antigen receptors (CARs). In some embodiments, the methods are for treating subjects with non-Hodgkin lymphoma (NHL). In some embodiments, the methods are for treating subjects with relapsed or refractory NHL. Also provided are articles of manufacture and prophylactic treatments in connection with adoptive therapy methods.