Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer

US11945812B2 · kind B2 · utility

Assignees

• Boehringer Ingelheim International GmbH · DE
• VANDERBILT UNIVERSITY · US

Inventors

• Jason ABBOTT · Libertyville, US
• Joachim BROEKER · Miedling, AT
• Jianwen CUI · Ridgefield, US
• Steve W. FESIK · Nashville, US
• Andreas Gollner · Wien, AT
• Tim HODGES · Chicago, US
• Jale KAROLYI-OEZGUER · Wien, AT
• Andrew LITTLE · Sudbury, US
• Andreas Mantoulidis · Wien, AT
• Jason Phan · Nashville, US
• Dhruba SARKAR · Hyderabad, IN
• Christian Alan Paul Smethurst · Wien, AT
• Qi Sun · Beijing, CN
• Matthias Treu · Wien, AT
• Alex G. Waterson · Durham, US

Key dates

• Filing date: Jun 1, 2021
• Grant date: Apr 2, 2024
• Expiry date: Jun 1, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention encompasses compounds of formula (I) wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, U, V, W, L and E have the meanings given in the claims and specification, their use as inhibitors of mutant Ras family proteins, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.