Long germline DH genes and long HCDR3 antibodies
US11946063B2 · kind B2 · utility
0Cited by
19References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 19, 2018 |
| Grant date | Apr 2, 2024 |
| Priority date | — |
| Expiry date | Oct 19, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2015/8527
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to a long DH (LDH) cassette comprising a recombinant DH construct comprising at least two DH gene segments encoding at least 10 amino acids of the HCDR3 amino acid sequence, wherein at least one of the DH gene segments is a heterologous DH gene segment; an immunoglobulin heavy chain locus and a transgenic non-human animal comprising the same; and their use in producing an immunoglobulin library with long HCDR3 regions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.