Detection method of polyethylene glycol monomethyl ether residue in medicinal materials
US11946917B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 14, 2020 |
| Grant date | Apr 2, 2024 |
| Priority date | — |
| Expiry date | Feb 2, 2043 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/885
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A detection method of polyethylene glycol monomethyl ether residue in medicinal materials is provided, which belongs to a technical field of medicinal chemical component detection, and includes: detecting a residual amount of mPEG-2000 in 3000-3400 small-molecule mPEG-b-PDLLA by high-performance liquid chromatography with an evaporative light scattering detector. The present invention solves a problem that the copolymer polyethylene glycol monomethyl ether mPEG and the product polyethylene glycol monomethyl ether-polylactic acid block copolymer mPEG-b-PDLLA are difficult to be separated in the high-performance liquid chromatography and there is no UV absorption. The present invention also has high resolution, high sensitivity, sufficient reproducibility and sufficient selectivity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.