Preservation of pancreatic islet grafts in the extrahepatic space

US11951136B2 · kind B2 · utility

Assignees

• The Regents of the University of California · US
• United States Government as represented by the Department of Veterans Affairs · US

Inventors

• Casey Ward · San Francisco, US
• Qizhi Tang · Oakland, US
• Peter STOCK · San Francisco, US
• Gaetano FALEO · San Francisco, US
• Gopika NAIR · San Francisco, US
• Matthias Hebrok · Belmont, US
• Wenhan Chang · San Francisco, US
• Thuy Vo · San Francisco, US
• Jeffrey A. Bluestone · San Francisco, US
• Eleonora DE KLERK · San Francisco, US

Key dates

• Filing date: Dec 12, 2018
• Grant date: Apr 9, 2024
• Expiry date: May 1, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2506/078
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein, inter alia, are methods and compositions for treating diabetes mellitus comprising co-transplantation of an insulin-producing cell and a cell derived from a parathyroid gland (PTG), a CD34+ cell derived from a parathyroid gland, a CD34+ cell derived from a stem cell, or other progenitor cell-derived CD34+ cell.