RNA constructs and uses thereof

US11951185B2 · kind B2 · utility

Assignee

• BIONTECH SE · DE

Inventors

• Ugur Sahin · Mainz, DE
• Gábor Boros · Mainz, DE
• Azita Josefine Mahiny · Mainz, DE
• Jonas Reinholz · Mainz, DE
• Katalin Kariko · Rydal, US

Key dates

• Filing date: Dec 30, 2021
• Grant date: Apr 9, 2024
• Expiry date: Dec 30, 2041

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are RNA polynucleotides comprising a 5′ Cap, a 5′ UTR comprising a cap proximal sequence disclosed herein, and a sequence encoding a payload. Also disclosed herein are compositions and medical preparations comprising the same, and methods of making and using the same.