Hemostatic composition and preparation method therefor
US11951228B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 28, 2020 |
| Grant date | Apr 9, 2024 |
| Priority date | — |
| Expiry date | Oct 21, 2040 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L24/08
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Provided is a hemostatic composition comprising trypsin and zeolite, wherein pore channels of the zeolite are micropores, the zeolite contains divalent metal cations, and the mass ratio of the trypsin to the zeolite is 1:200-4:10. In the present invention, the trypsin specifically binds to the zeolite, allowing the trypsin to maintain a certain conformation on the surface of the zeolite and to obtain a higher procoagulant activity, thereby obtaining a hemostatic composition with an excellent blood coagulation effect. The hemostatic composition of the present invention has the advantages of a simple preparation method, low cost and convenient use, and can be widely used in hemostasis during trauma and operations, especially in emergent hemostasis in hemophilia patients.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.