Microfluidic system, method for inhibiting, delaying, or reversing cellular senescence using microfluidic system, and cell obtained therefrom
US11951479B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jul 29, 2021 |
| Grant date | Apr 9, 2024 |
| Priority date | — |
| Expiry date | Dec 9, 2041 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01L2400/0478
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a method of inhibiting, delaying, or reversing cellular senescence that includes having an isolated cell flow through a microchannel, and crashing the cell in flow into an impact surface installed on a flow path of the cell to apply a physical impact to the cell, resulting in inhibiting, delaying, or reversing senescence of the cell, while maintaining high biological activity, and in particular, it relates to a method that can further increase the value of a stem cell as a therapeutic cell for various degenerative diseases by maintaining undifferentiated state of the stem cell even during a long-term culture period to maintain multipotency, and to the cells obtained by the method.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.