Method of preparing high chiral purity lactam intermediate and brivaracetam
US11952341B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Dec 17, 2018 |
| Grant date | Apr 9, 2024 |
| Priority date | — |
| Expiry date | Jun 14, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/07
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention discloses a method of preparing a high chiral purity lactam intermediate D comprising a step of reducing a compound C to lactam intermediate D in a solvent by hydrogenation reduction using a heavy metal catalyst and a chiral inducer. Brivaracetam can be prepared in a single step using the lactam intermediate D. The synthesis route is short, reaction conditions are mild, post-treatment is simple, reaction yield is high, chiral selectivity is good, and production cost is low. The conversion rate of the compound C in the reaction is 81%, and the DE value of the compound D is more than 99.0%, which is suitable for industrial production.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.