Small molecule modulators of PAR2 and uses thereof
US11952379B2 · kind B2 · utility
0Cited by
0References
22Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Apr 9, 2019 |
| Grant date | Apr 9, 2024 |
| Priority date | — |
| Expiry date | Feb 9, 2041 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K45/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention is in the field of medicinal pharmacology. In particular, the invention relates to a new class of small-molecules having a pyrazino-pyrimidine-dione (or related) structure which function as modulators (activators, inhibitors) of protease activated receptor type 2 (PAR2), and their use as therapeutics for the treatment of conditions involving PAR2 activity (e.g., asthma, chronic pain, cancer and/or vascular disorders).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.