HPV-specific binding molecules

US11952408B2 · kind B2 · utility

Assignees

• Juno Therapeutics, Inc. · US
• Editas Medicine, Inc. · US

Inventors

• Cameron S. Brandt · Seattle, US
• Brian J. Belmont · Cambridge, US
• Christopher Borges · Cambridge, US
• Stephen Michael Burleigh · Seattle, US
• Alexandra Croft · Seattle, US
• Stephen J. Goldfless · Seattle, US
• David Jeffrey HUSS · Seattle, US
• Yue JIANG · Seattle, US
• Timothy G. JOHNSTONE · Seattle, US
• David KOPPSTEIN · Seattle, US
• Hieu Huu Nguyen · Seattle, US
• Christopher Heath NYE · San Jose, US
• Haley Peper · Seattle, US
• Blythe SATHER · South San Francisco, US
• Sonia Timberlake · Brookline, US
• Dean Y. Toy · Seattle, US
• Queenie VONG · South San Francisco, US
• Gordon Grant Welstead · Cambridge, US
• James Sissons · Seattle, US

Key dates

• Filing date: Sep 28, 2018
• Grant date: Apr 9, 2024
• Expiry date: Mar 8, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2800/80
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are binding molecules, such as TCRs or antigen binding fragments thereof and antibodies and antigen-binding fragments thereof, such as those that recognize or bind human papilloma virus (HPV) 16, including HPV 16 E6 and HPV 16 E7. Also provided are engineered cells containing such binding molecules, compositions containing the binding molecules or engineered cells, and methods of treatment, such as administration of the binding molecules, engineered cells, or compositions.