Yarrowia lipolytica yeast strains expressing an HMG-CoA reductase having increased activity or expression

US11952577B2 · kind B2 · utility

Assignee

• NUCELIS LLC · US

Inventors

• Keith A. M. Walker · Los Altos Hills, US
• Mark E. Knuth · Redwood City, US
• Noel M. Fong · San Diego, US
• Peter R. Beetham · Carlsbad, US

Key dates

• Filing date: Jan 9, 2017
• Grant date: Apr 9, 2024
• Expiry date: Jan 9, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12R2001/73
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Provided herein compositions and methods for producing isoprenoids, including squalene. In certain aspects and embodiments provided are genetically converted yeast and uses therefore. In some aspects and embodiments, the genetically converted yeast produce isoprenoids, preferably squalene. Also are provided methods of producing squalene using a genetically converted yeast or a non-genetically converted yeast. The invention also provides squalene produced by genetically converted yeast or non-genetically converted yeast.