Application of glutamate dehydrogenase GDHA of Peptostreptococcus asaccharolyticus in increasing yield of poly-r-glutamic acid from Bacillus licheniformis
US11952596B2 · kind B2 · utility
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Key dates
| Filing date | Sep 30, 2020 |
| Grant date | Apr 9, 2024 |
| Priority date | — |
| Expiry date | Jul 10, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12R2001/10
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Application of glutamate dehydrogenase GdhA of Peptostreptococcus asaccharolyticus in increasing the yield of poly-γ-glutamic acid from Bacillus licheniformis. The glutamate dehydrogenase GdhA of the Bacillus licheniformis WX-02 per se is replaced with the glutamate dehydrogenase derived from the Peptostreptococcus asaccharolyticus by means of homologous recombination, which significantly increases the level of synthesizing the poly-γ-glutamic acid for the Bacillus licheniformis, and the yield of the obtained poly-γ-glutamic acid from strains is increased at least by more than 20% compared with control strains.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.