Genetically modified mouse expressing human APOE4 and mouse Trem2 p.R47H and methods of use thereof
US11957115B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 21, 2018 |
| Grant date | Apr 16, 2024 |
| Priority date | — |
| Expiry date | Apr 12, 2040 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Genetically modified mice characterized by one or more symptoms or signs associated with expression of human APOE4p and mouse Trem2p and relevant to non-familial late-onset Alzheimer's disease are provided wherein the genome of the mouse includes: 1) a DNA sequence encoding a human APOE4 protein (APOE4p) operably linked to a promoter; and 2) a DNA sequence encoding a mouse Trem2 protein having a mutation p,R47H (Trem2p) operably linked to a promoter, such that the mouse expresses human APOE4p and mouse Trem2p. Methods ace provided for screening for a compound for use in the treatment of Alzheimer's disease using such genetically modified mice.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.