Protein-type nanoparticles, preparation methods, and application thereof
US11957764B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 27, 2023 |
| Grant date | Apr 16, 2024 |
| Priority date | — |
| Expiry date | Jan 27, 2043 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/6929
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The disclosure relates to a protein-type nanoparticle for multi-specific antibody delivery, a preparation method, and its application. The protein-type nanoparticle includes a polyester and a protein with a hydrophobic domain, and the hydrophobic domain of the protein is bound with the polyester through hydrophobic interactions. The protein is at least one of albumin, globulin and cell wall protein. The protein-type nanoparticle of the present disclosure has excellent stability and biocompatibility. The protein-type nanoparticle is used to prepare a multi-specific antibody delivery platform (αFc-NP) by binding anti-IgG-Fc antibody or anti-IgG-Fc antibody fragment, which can stably, quickly and easily bind to multiple specific antibodies through antigen-antibody interaction and enhance the therapeutic effect of specific antibodies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.