Modified TNF as a capture ligand
US11957825B2 · kind B2 · utility
0Cited by
2References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 17, 2022 |
| Grant date | Apr 16, 2024 |
| Priority date | — |
| Expiry date | Jun 17, 2042 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M1/3496
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A column is disclosed for removal of sTNF-R2 from a body fluid. The column has a compartment, an inlet coupled to the compartment and configured to receive the body fluid, and a substrate disposed within the compartment. A capture ligand is coupled to the substrate and has a modified sequence with an amino acid substitution in a reference sequence that includes a portion of a natural TNF sequence. The modified sequence has an affinity for the sTNF-R2 that is greater than an affinity of the reference sequence for the sTNF-R2.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.