Inhibitors of bacterial glutaminyl cyclases for use in the treatment of periodontal and related diseases

US11958871B2 · kind B2 · utility

Assignee

• Fraunhofer-Gesellschaft zur förderung der angewandten Forschung e.V. · DE

Inventors

• Christian Jäger · Berlin, DE
• Linda Liebe · Dohnsen, DE
• Daniel Ramsbeck · Halle (Saale), DE
• Miriam Linnert · Dohnsen, DE
• Stefanie Geissler · Dohnsen, DE
• Anke Piechotta · Bodenwerder, DE
• Diane Meitzner · Wolfen, DE
• Holger Cynis · Dohnsen, DE
• Mirko Buchholz · Halle (Saale), DE

Key dates

• Filing date: Feb 22, 2019
• Grant date: Apr 16, 2024
• Expiry date: Aug 1, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to novel compounds which are particularly useful as inhibitors of bacterial glutaminyl cyclases (bacQC); pharmaceutical compositions comprising such compounds; compounds and/or pharmaceutical compositions for use in methods for treatment, in particular for use in the treatment of periodontitis and related conditions; as well as to crystals comprising bacterial glutaminyl cyclases, methods for identifying candidate compounds which may associate with the binding pocket of a bacQC and/or are bacQC inhibitors.