Representative diagnostics

US11959838B2 · kind B2 · utility

Assignee

• Ventana Medical Systems, Inc. · US

Inventors

• Nelson Alexander · Marana, US
• Aoune Barhoumi · Oro Valley, US
• Melinda Day · Oro Valley, US
• Lisa Gallegos · Tucson, US
• Katherine Leith · Tucson, US
• Samantha Rajkovich · Marana, US
• Esteban Roberts · Tucson, US
• Stacey Stanislaw · Tucson, US
• Eric Walk · Tucson, US

Key dates

• Filing date: Apr 27, 2018
• Grant date: Apr 16, 2024
• Expiry date: Apr 27, 2038

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/52
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The disclosure generally relates to the preparation of representative samples from clinical samples, e.g., tumors (whole or in part), lymph nodes, metastases, cysts, polyps, or a combination or portion thereof, using mechanical and/or biochemical dissociation methods to homogenize intact samples or large portions thereof. The resulting homogenate provides the ability to obtain a correct representative sample despite spatial heterogeneity within the sample, increasing detection likelihood of low prevalence subclones, and is suitable for use in various diagnostic assays as well as the production of therapeutics, especially “personalized” anti-tumor vaccines or immune cell based therapies.