Molecular wires for detecting a biological or chemical entity or event
US11959915B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 1, 2023 |
| Grant date | Apr 16, 2024 |
| Priority date | — |
| Expiry date | May 1, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/6816
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method of fabricating a device includes fabricating conductive surfaces including one or more capture surfaces and one or more reference surfaces, attaching a first molecular wire to each capture surface, and attaching a second molecular wire to each reference surface. The first and second molecular wires include chiral oligonucleotide multiplexes having identical nucleobase sequences and opposite absolute configuration. The first molecular wire includes a first oligonucleotide strand conjugated to a first functional handle including a sulfur-containing compound, and a second oligonucleotide strand conjugated to a capture agent that interacts with a target entity. The second molecular wire includes a first oligonucleotide strand conjugated to a second functional handle including a sulfur-containing compound, and a second oligonucleotide strand conjugated to a reference compound. The first and second oligonucleotide strands of each molecular wire are complementary and have the same absolute configuration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.