Preparation method of ginseng composition with high ginsenoside bioavailability
US11963970B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Sep 13, 2023 |
| Grant date | Apr 23, 2024 |
| Priority date | — |
| Expiry date | Sep 13, 2043 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure discloses a preparation method of ginseng composition with high ginsenoside bioavailability. The composition is composed of ginseng powder of 250 meshes or more and β-cyclodextrin, and the mass ratio of the ginseng powder to the β-cyclodextrin is 1:0.05. Results show that when β-cyclodextrin is used as a solid dispersant and added to the 1000-mesh ginseng powder at a mass ratio of 5%, the total dissolution amount is maximum; and furthermore, animal experiments (SD rats) show that the area under the plasma drug concentration-time curve (AUC0-48 h) after 48 h of ginseng powder ingestion is maximum, indicating that in-vivo bioavailability of the ginseng powder is the highest. The method of this application can effectively inhibit the aggregation of the ultra-finely pulverized 1000-mesh ginseng powder by adding the β-cyclodextrin, thus significantly improving the total dissolution amount of ginsenoside.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.