Small molecule binders of the oncogenic fusion transcription factor PAX3-FOXO1

US11964022B2 · kind B2 · utility

Assignees

• Massachusetts Institute of Technology · US
• UNIVERSITÄT ZÜRICH · CH

Inventors

• Angela N. Koehler · Cambridge, US
• Shelby Doyle · Cambridge, US
• Becky Leifer · Malden, US
• Madeleine Henley · Watertown, US
• Beat W. Schaefer · Zürich, CH
• Marco Wachtel · Zürich, CH

Key dates

• Filing date: Sep 16, 2022
• Grant date: Apr 23, 2024
• Expiry date: Sep 16, 2042

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides compounds having the general formula P-L-U, or pharmaceutically acceptable salts thereof, wherein P is a FOXO1 fusion protein binding moiety, L is a bivalent linker, and U is an ubiquitin ligase binding moiety. Also provided are pharmaceutical compositions containing such compounds and methods of using such compounds.