Antigen binding molecule formats

US11965020B2 · kind B2 · utility

Assignee

• REGENERON PHARMACEUTICALS, INC. · US

Inventors

• Tong Zhang · Beijing, CN
• Erica Pyles · New City, US
• Michael Rosconi · New City, US
• Nina Liu · Chappaqua, US
• Supriya Patel · Mamaroneck, US
• Eric Smith · New York, US
• Andrew J. Murphy · Croton-on-Hudson, US
• Chia-Yang Lin · Palo Alto, US
• Samuel Davis · New York, US

Key dates

• Filing date: May 17, 2023
• Grant date: Apr 23, 2024
• Expiry date: May 17, 2043

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/94
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.