Programmable protein circuits in living cells

US11965191B2 · kind B2 · utility

Assignee

• CALIFORNIA INSTITUTE OF TECHNOLOGY · US

Inventors

• Xiaojing Gao · Pasadena, US
• Lucy S. Chong · Pasadena, US
• Michael B. Elowitz · Los Angeles, US
• Mark W. Budde · Arcadia, US
• Matthew Kim · San Francisco, US

Key dates

• Filing date: Jan 25, 2021
• Grant date: Apr 23, 2024
• Expiry date: Oct 31, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/50
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present disclosure relates to systems, methods and compositions provided herein that include a compound protease. The compound protease can contain a protease domain, a cut site for another enzyme and an association domain. In some embodiments, the compound protease is part of a protein circuit.