Method for diagnosing and assessing endometriosis
US11965879B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Aug 21, 2020 |
| Grant date | Apr 23, 2024 |
| Priority date | — |
| Expiry date | Feb 4, 2042 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/364
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of detecting the expression level of miRNA markers in a biological sample obtained from a mammal is provided. The method incudes the steps of i) detecting the expression level of one or more miRNA markers selected from the group of miR-199a-3p, miR-143-3p, miR-340-5p, let-7b-5p, miR-21-5p, miR-17-5p, miR-20a-5p and miR-103a-3p, in the biological sample; ii) detecting the expression level of at least one miRNA reference marker selected from miR-148b-3p and miR-30e-5p in the biological sample; and iii) normalizing the expression level of the miRNA marker(s) against the expression level of the miRNA reference marker in the sample and in a control. The method is useful for the diagnosis of endometriosis, monitoring of patient response to treatment, and assessment of disease progression and/or severity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.