Use of immune modulators to improve nerve regeneration

US11969522B2 · kind B2 · utility

Assignees

• The Board of Regents of the University of Texas System · US
• Edward Keefer · US

Inventors

• Jonathan Cheng · Alhambra, US
• Edward Keefer · Dallas, US
• Srikanth Vasudevan · Monroe, US

Key dates

• Filing date: Jul 7, 2020
• Grant date: Apr 30, 2024
• Expiry date: Apr 1, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D257/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure describes the use of immune modulators to promote nerve growth and regeneration, particularly in the context of nerve deficit stemming from trauma and disease. In particular, the disclosure provides for the use of CXCR4 antagonsists, STAT3 activators, and an agent that increase nitric oxide, alone or in combination, to treat nerve deficit conditions.