Monomers capable of dimerizing in an aqueous solution, and methods of using same

US11970448B2 · kind B2 · utility

Assignees

• Cornell University · IT
• Purdue Research Foundation · US

Inventors

• Francis Barany · Baltimore, US
• Maneesh Pingle · New York, US
• Donald E. Bergstrom · West Lafayette, US
• Sarah F. Giardina · New York, US
• Lee D. Arnold · Rancho Santa Fe, US

Key dates

• Filing date: Jul 15, 2020
• Grant date: Apr 30, 2024
• Expiry date: Jul 15, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F5/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.