Gene expression markers for predicting overall survival in subjects treated with sipuleucel-T
US11970743B2 · kind B2 · utility
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Key dates
| Filing date | Sep 9, 2019 |
| Grant date | Apr 30, 2024 |
| Priority date | — |
| Expiry date | Dec 4, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Gene expression profiling in patients with mCRPC identifying genes that predict overall survival in response to treatment with sipuleucel-T, the method comprising the steps of (a) determining a gene expression level of a first biomarker; (b) determining a gene expression level of at least one additional biomarker different from the first biomarker; and (c) transforming the expression level of the first biomarker and the at least one additional biomarker into a first score corresponding to a probability of overall survival in response to treatment with sipuleucel-T.
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