Compositions and methods for immune repertoire sequencing
US11970787B2 · kind B2 · utility
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6References
12Claims
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Key dates
| Filing date | Feb 4, 2021 |
| Grant date | Apr 30, 2024 |
| Priority date | — |
| Expiry date | Sep 8, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/166
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present disclosure provides methods, compositions, kits, and systems useful in the determination and evaluation of the immune repertoire. In one aspect, target-specific primer panels provide for the effective amplification of sequences of T cell receptor and/or B cell receptor chains with improved sequencing accuracy and resolution over the repertoire. Variable regions associated with the immune cell receptor are resolved to effectively portray clonal diversity of a biological sample and/or differences associated with the immune cell repertoire of a biological sample.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.