Method for preparing beta-lactam derivative
US11976060B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | Sep 4, 2019 |
| Grant date | May 7, 2024 |
| Priority date | — |
| Expiry date | Jul 9, 2041 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2531/16
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a method for preparing a β-lactam derivative, wherein a substituted N-quinoline-3-butenamide derivative is used as a substrate to react with a toluene derivative or a heterocyclic derivative at 90-150° C. in the presence of DTBP and a copper salt catalyst, to prepare a β-lactam derivative. According to the method of the present invention, a variety of β-lactam derivatives can be obtained with a high yield. The reaction of the present invention has mild reaction conditions, and simple reaction operation and post-treatment process, and is suitable for large-scale production.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.