Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-α]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms therof

US11976077B2 · kind B2 · utility

Assignee

• Abb Vie Inc. · US

Inventors

• Aileen L. Pangan · La Grange, US
• Henrique D. Teixeira · Green Oaks, US
• Mohamed-Eslam F. Mohamed · Gurnee, US
• Ahmed A. Othman · Libertyville, US
• Ben Klünder · Ludwigshafen, DE
• Jeffrey W. Voss · Hudson, US
• Robert J. Padley · Highland Park, US
• Heidi S. Camp · Winnetka, US

Key dates

• Filing date: Mar 1, 2023
• Grant date: May 7, 2024
• Expiry date: Mar 1, 2043

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and atopic dermatitis), kits, methods of synthesis, and products-by-process.