Sodium hyaluronate with full molecular weight distribution (MWD), and preparation method and use thereof
US11976139B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jul 31, 2022 |
| Grant date | May 7, 2024 |
| Priority date | — |
| Expiry date | Jul 31, 2042 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01D2325/34
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A preparation method of sodium hyaluronate with a full molecular weight distribution (MWD) is provided, including: step 1): spraying hydrogen peroxide on a sodium hyaluronate solid raw material, and conducting an ultraviolet (UV) irradiation treatment; step 2): dissolving a sodium hyaluronate degradation material in water, and adjusting a pH to higher than 7.0; step 3): subjecting a sodium hyaluronate alkaline solution to an ultrasonic treatment; step 4): preparing the sodium hyaluronate solid raw material into a sodium hyaluronate solution with a concentration of 0.1% to 1% (w/v), and thoroughly mixing the sodium hyaluronate solution in an addition proportion of 20% to 60% (v/v) with the sodium hyaluronate alkaline solution obtained after the ultrasonic treatment; and step 5): subjecting a resulting mixed solution to an adsorption treatment with diatomaceous earth and activated carbon, filtering for concentration, and drying a resulting concentrate to obtain the sodium hyaluronate with a full MWD.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.