Device and method for determining the depth of a subsurface fluorescent object within an optically absorbing and scattering medium and for determining concentration of fluorophore of the object
US11977027B2 · kind B2 · utility
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28Claims
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Key dates
| Filing date | May 26, 2023 |
| Grant date | May 7, 2024 |
| Priority date | — |
| Expiry date | May 26, 2043 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2201/062
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth.
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