Bi-functional compounds and methods for targeted ubiquitination of androgen receptor
US11981672B2 · kind B2 · utility
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19Claims
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Key dates
| Filing date | Sep 13, 2022 |
| Grant date | May 14, 2024 |
| Priority date | — |
| Expiry date | Sep 13, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to bi-functional compounds which function to recruit endogenous proteins to an E3 ubiquitin ligase for degradation, and methods for using same. More specifically, the present disclosure provides specific proteolysis targeting chimera (PROTAC) molecules which find utility as modulators of targeted ubiquitination of a variety of polypeptides and other proteins, in particular the androgen receptor of a slice variant of AR which lacks the LBD, labelled as AR-V7, which are then degraded and/or otherwise inhibited by the compounds as described herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.