Fluoro-pyridinone phosphates and boronates useful as antibacterial agents

US11981696B2 · kind B2 · utility

Assignee

• PFIZER INC. · US

Inventors

• Tamim F. Braish · Ledyard, US
• Matthew Frank Brown · Stonington, US
• Ye Che · Groton, US
• Richard Andrew Ewin · Kalamazoo, US
• Timothy Allan Johnson · Richland, US
• Michael Joseph Melnick · Portage, US
• Justin Ian Montgomery · Ledyard, US
• Mark Plummer · Westbrook, US
• Loren Michael Price · Groton, US
• Usa Reilly · West Haven, US
• Daniel Paul Uccello · Colchester, US

Key dates

• Filing date: Mar 14, 2019
• Grant date: May 14, 2024
• Expiry date: Sep 11, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F5/022
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to a new fluoro-pyridinone hydroxamic acid phosphates and boronates of Formulae I, II and III wherein Q is selected from the group consisting of —P(O)(OH)2, —P(O)(OH)(O−M+), —P(O)(O−M+)2 and —P(O)(O−)2M2+; M+ at each occurrence is a pharmaceutically acceptable monovalent cation; and M2+ is a pharmaceutically acceptable divalent cation and their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.