Polynucleotide constructs
US11981703B2 · kind B2 · utility
1Cited by
124References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 17, 2017 |
| Grant date | May 14, 2024 |
| Priority date | — |
| Expiry date | Sep 29, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/322
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed are polynucleotide constructs having a strand linked to a moiety carrying one or more auxiliary moieties. Also disclosed are polynucleotide constructs interrupted with a sugar analogue, and polynucleotide constructs with stereochemical{circumflex over ( )} enriched phosphorothioates. The polynucleotide constructs may be provided as hybridized polynucleotide constructs. Also featured are methods of delivery a polynucleotide construct to a cell and methods of reducing the expression of a protein in a cell by contacting the cell with the disclosed polynucleotide construct or hybridized polynucleotide construct.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.