Methods and compositions for delivery of immunotherapy agents across the blood-brain barrier to treat brain cancer
US11981705B2 · kind B2 · utility
1Cited by
11References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 8, 2021 |
| Grant date | May 14, 2024 |
| Priority date | — |
| Expiry date | Jan 8, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14171
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present application relates to sequences that enhance permeation of immunotherapy agents across the blood brain barrier (BBB), compositions comprising the sequences, and methods of use thereof to treat brain cancer, e.g., glioblastoma (GBM). Further disclosed are a number of potential targeting peptide sequences identified that enhance permeation through the BBB, when inserted into the capsid of an adeno-associated virus (AAV).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.