Chimeric polypeptide assembly and methods of making and using the same
US11981744B2 · kind B2 · utility
0Cited by
94References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 19, 2022 |
| Grant date | May 14, 2024 |
| Priority date | — |
| Expiry date | Dec 19, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2523/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to bispecific chimeric polypeptide assembly compositions comprising bulking moieties linked to binding domains by cleavable release segments that, when cleaved are capable of concurrently binding effector T cells with targeted tumor or cancer cells and effecting cytolysis of the tumor cells or cancer cells. The invention also provides compositions and methods of making and using the cleavable chimeric polypeptide assembly compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.