Supercentenarian induced pluripotent stem (sciPS) cells and methods of making and using thereof
US11981930B2 · kind B2 · utility
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19Claims
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Key dates
| Filing date | Dec 2, 2020 |
| Grant date | May 14, 2024 |
| Priority date | — |
| Expiry date | Jun 21, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2506/1346
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Provided herein are cells and methods for reprogramming iPS cells from a supercentenarian and their differentiated derivatives having differences from non-supercentenarian iPS derived cells that contribute to disease resistance and longevity. Additionally, provided herein are methods for treatment and prevention of age related diseases by administration of therapeutic sciPS derived cells or cell derived reagents. Also provided herein, are methods for identifying reagents for treatment of age related diseases using sciPS cell-based assays.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.