Methods for treating heart failure by administering cardiac sarcomere activators
US11986474B1 · kind B1 · utility
Assignee
Inventor
Key dates
| Filing date | Jun 27, 2023 |
| Grant date | May 21, 2024 |
| Priority date | — |
| Expiry date | Jun 27, 2043 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for treating heart failure are described herein. Treatment methods include administering a cardiac sarcomere activator (e.g., omecamtiv mecarbil, or a pharmaceutically acceptable salt and/or hydrate thereof) to a subject in need thereof. Treatment methods also include adjusting a dose level of the CSA, for example, to increase, decrease, or maintain a dose level, based on the subject's plasma concentration of the CSA determined after administration of the first dose level of the CSA has started. Provided herein are also treatment methods effective to achieve a target concentration range of the CSA and dose in a single step following a single plasma concentration determination.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.