Salts, crystal forms, and production methods thereof

US11987591B2 · kind B2 · utility

Assignee

• Sumitomo Pharma America, Inc. · US

Inventors

• Andrea Bauer · North Reading, US
• Nandkumar Nivritti BHOGLE · Shrewsbury, US
• Xiaoxia Chen · Beijing, CN
• Shahla Jamzad · Belmont, US
• Robert Joseph PRYTKO · Millbury, US
• Kostas Saranteas · Peabody, US
• Michael J. Sizensky · Grafton, US
• Harold Scott Wilkinson · Westborough, US
• Haitao Zhang · Ithaca, US

Key dates

• Filing date: Jul 22, 2022
• Grant date: May 21, 2024
• Expiry date: Jul 22, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are salts of (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine and various of crystal forms thereof, and compositions, medicaments, pharmaceutically acceptable formulations thereof, and methods of making same. In addition, provided are compounds comprising specific particle size distributions of crystalline (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine HCl and methods of making and modulating the particle size distributions.