Polymeric forms of H-NOX proteins
US11987614B2 · kind B2 · utility
0Cited by
17References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 9, 2021 |
| Grant date | May 21, 2024 |
| Priority date | — |
| Expiry date | Aug 9, 2041 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides polymeric H-NOX proteins for the delivery of oxygen with longer circulation half-lives compared to monomeric H-NOX proteins. Polymeric H-NOX proteins extravasate into and preferentially accumulate in tumor tissue for sustained delivery of oxygen. The invention also provides the use of H-NOX proteins as radiosensitizers for the treatment of brain cancers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.