Resorbable complex shape memory poly(propylene fumarate) star scaffolds for 4D printing applications
US11987668B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 15, 2021 |
| Grant date | May 21, 2024 |
| Priority date | — |
| Expiry date | Jul 15, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08G63/918
- WIPO fieldMacromolecular chemistry, polymers
- WIPO sectorChemistry
Abstract
In one or more embodiments, the present invention provides am method of making a poly(propylene fumarate-co-succinate) (PPFS) copolymer containing a random incorporation of succinate groups and targetable reduction profiles without the need for three or more monomer units. To achieve this, a time-dependent sonication-promoted zinc/acetic acid reduction of the PPM unsaturated double bonds has been used to create a random PPMS copolymer which may be isomerized into the PPFS equivalent. By changing the sonication time as well as the ratios of acetic acid, zinc, and PPM unsaturated alkenes, partial reduction of the PPM alkenes has been shown to give PPMS products containing varying compositions of succinic and maleate units, which may then be isomerized to the PPFS product.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.