L-glass: a novel functionalization method for covalently attaching ECM protein to optical glass
US11987780B2 · kind B2 · utility
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4References
11Claims
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Assignee
Inventors
Key dates
| Filing date | Jul 13, 2018 |
| Grant date | May 21, 2024 |
| Priority date | — |
| Expiry date | May 21, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC03C2218/11
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Described herein is functionalized glass allowing for robust attachment of extracellular matrix proteins (ECM) withstanding extended culturing periods. By first treating glass with a sulfur silane reagent, the treated glass can be activated via an amine-sulfur linker, after which ECM proteins are attached to the linker. The Inventors observed that this glass treatment combination (sulfur silane-linker-ECM) resisted degradation when compared to conventional surface coatings, such as poly-L-orthinine coated glass.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.